Thermo Fisher Scientific TRMT12 Polyclonal Antibody
TRMT12 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 최적화. 인간 및 생쥐 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관.
- 카탈로그번호
- PA521153
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.5 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the amino terminus of human TYW2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157838 |
Product Specific Information
- A suggested positive control is K562 cell lysate.
- PA5-21153 can be used with blocking peptide PEP-1267.
Target Information
TYW2 (also known as TRM12) is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA, stabilizing codon-anticodon interactions during decoding on the ribosome.
TYW2 is involved in a multistep enzymatic reaction that ensures correct translation by stabilizing base-pairing during ribosomal decoding.
TYW2 has been found amplified in 7 of 8 breast cancer cell lines, and overexpressed (>2-fold) in 26 of 30 breast tumors by qPCR, suggesting a potential role in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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