Thermo Fisher Scientific Complement Factor Bb Neoantigen Monoclonal Antibody (032B-22.1.X)

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

This antibody recognizes a neoantigen of the Bb fragment of human complement factor B. Factor B is present in blood serum. C3b associates with complement factor B, inducing a conformational change that enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b to form C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits lymphocyte proliferation.

Target Information

CFB is involved in hemolytic uremic syndrome atypical 4 (AHUS4), an atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure, and absence of enterocolitis and diarrhea episodes. Atypical forms have poorer prognosis, higher mortality, and frequent progression to end-stage renal disease. Disease susceptibility is associated with variations affecting the CFB gene and other regulatory factors in the complement cascade system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.