Thermo Fisher Scientific NBD1 Monoclonal Antibody (ZY357)
인간 NBD1 단백질(aa 350-450)을 면역원으로 제작된 Mouse IgG1 단클론 항체. Western blot 및 IHC(P)에서 검증됨. 단백질 A로 정제된 액상형 항체로, 단기 4°C, 장기 -20°C 보관 권장. CFTR 연구 및 낭포성 섬유증 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZY357 |
| Immunogen | Recombinant protein corresponding to amino acids 350–450 of human NBD1 (CFTR, UniProt ID: P13569-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Cystic fibrosis
- Cellular location: Nucleus
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases involve deletion of phenylalanine at position 508 (ΔF508), leading to defective chloride transport.
This mutation often results in severe lung and liver disease. Interestingly, CFTR also serves as an entry point for Salmonella typhi into intestinal epithelial cells, and ΔF508 mutations in mice have shown significant reductions (86–100%) in S. typhi uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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