Thermo Fisher Scientific NBD1 Monoclonal Antibody (ZY356)
인간 NBD1 단백질(aa 440-540)을 면역원으로 제작된 마우스 단클론 항체. Western blot 및 IHC(파라핀) 분석에 적합. 단백질 A로 정제된 액상 항체로, 0.5 mg/mL 농도. CFTR 관련 연구 및 낭포성 섬유증 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZY356 |
| Immunogen | Recombinant protein corresponding to amino acids 440–540 of human NBD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C (short term). For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Cystic fibrosis
- Cellular location: Nucleus
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Approximately 70% of CF cases share a deletion of phenylalanine at position 508 (ΔF508), resulting in abnormal chloride transport. This mutation leads to severe lung and liver disease. Interestingly, CFTR is also used by Salmonella typhi to enter intestinal epithelial cells, and ΔF508 heterozygote and homozygote mice show significantly reduced S. typhi intestinal uptake.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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