Thermo Fisher Scientific Hemoglobin alpha Recombinant Rabbit Monoclonal Antibody (SN70-09)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
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Immunohistochemistry (IHC)

• Tested Dilution: –
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Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100
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Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to rabbit immune repertoire

Target Information

The human alpha globin gene cluster on chromosome 16 spans approximately 30 kb and includes seven loci: 5′-zeta–pseudozeta–mu–pseudoalpha-1–alpha-2–alpha-1–theta–3′.
The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical but differ in untranslated and intron regions.
Two alpha chains plus two beta chains form HbA, which constitutes ~97% of adult hemoglobin. Alpha chains combine with delta chains to form HbA2, and with gamma chains to form HbF.
Alpha thalassemias result from deletions of one or both alpha genes (HBA2 and HBA1) or from non-deletion mutations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.