Thermo Fisher Scientific Bcl-10 Recombinant Rabbit Monoclonal Antibody (SN74-04)
Recombinant rabbit monoclonal antibody recognizing human Bcl-10 protein. Validated for WB, IHC(P), and ICC/IF applications. Provides high specificity, sensitivity, and lot-to-lot consistency. Suitable for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN74-04 |
| Immunogen | Synthetic peptide within Human Bcl10 (aa 198–233) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809608 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response.
It promotes apoptosis, pro-caspase-9 maturation, and NF-κB activation via NIK and IKK.
BCL-10 acts as an adapter between the TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex, and is a substrate for MALT1.
Mutations in the BCL10 gene can lead to Immunodeficiency 37 or mucosa-associated lymphoid tissue (MALT) lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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