Thermo Fisher Scientific USP7 Monoclonal Antibody (GT481)
USP7 단백질을 인식하는 Mouse monoclonal antibody (Clone GT481). Western blot, ICC/IF, IP, ChIP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein G 정제, PBS buffer(20% glycerol) 용액 형태. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT481 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human USP7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787146 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (93%), Pig (97%), Chicken (93%).
- Positive control: 293T, A431, HeLa, HepG2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins. This deubiquitylating activity stabilizes its substrates by preventing their proteasomal degradation. USP7 is known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for tumor suppressor p53. Under normal conditions, Mdm2-mediated ubiquitylation keeps p53 levels low. In response to oncogenic stress, USP7 can deubiquitinate and stabilize p53, suggesting a tumor-suppressive role. Additionally, USP7 may participate in oncogenic stabilization of p53 through Myc or E1A pathways, potentially providing an alternative mechanism for cellular protection against oncogenic insults.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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