Thermo Fisher Scientific SOD2 Monoclonal Antibody (GT582)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as a concentrated solution.
• Predicted reactivity: Mouse (92%), Rat (94%), Zebrafish (88%), Xenopus laevis (86%), Pig (94%), Chicken (91%), Sheep (94%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (94%).
• Positive control: 293T, A431, HeLa, HepG2, mouse brain, rat brain.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS).
SOD catalyzes the dismutation reaction of superoxide radical anion (O₂) to hydrogen peroxide, which is then converted to water and oxygen by glutathione peroxidase and catalase.

There are several classes of SOD:

• SOD1 (Cu, Zn-SOD): Cytosolic enzyme found in all eukaryotic species; homodimeric 32 kDa enzyme containing one Cu and one Zn ion per subunit.
• SOD2 (Mn-SOD): Mitochondrial enzyme; 80 kDa tetrameric form located in the mitochondrial matrix near the respiratory chain.
• SOD3 (EC-SOD): Extracellular form; heparin-binding multimer of disulfide-linked dimers expressed in lungs, vessel walls, and airways.
• SOD4 (CCS): Copper chaperone for superoxide dismutase that delivers Cu to SOD1 and activates it by direct Cu cofactor insertion.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.