Thermo Fisher Scientific TGF beta-2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Transforming Growth Factor (TGF) betas mediate numerous cell-to-cell interactions during embryonic development. Three TGF betas (TGF beta 1, TGF beta 2, and TGF beta 3) have been identified in mammals. Each is synthesized as a precursor protein cleaved to yield a 112 amino acid polypeptide associated with the latent portion of the molecule.

TGF beta polypeptides are multifunctional and influence cell proliferation, differentiation, and other cellular functions. Both transformed and nonneoplastic tissues release transforming growth factors, and nearly all mammalian cells possess specific TGF receptors.

The multimodal nature of TGF beta is reflected in its ability to either stimulate or inhibit cellular proliferation. Generally, mesenchymal cells are stimulated, while epithelial or neuroectodermal cells are inhibited. TGF beta 1, TGF beta 2, and TGF beta 3 exhibit similar biological activities, with some variation in receptor binding. TGF beta 2 is produced by many cell types and found at high concentrations in porcine platelets and mammalian bone. Latent TGF beta 2 is the predominant isoform in body fluids such as amniotic fluid, breast milk, and ocular humors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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