Thermo Fisher Scientific KCNQ3 Polyclonal Antibody
KCNQ3 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(F), ICC/IF 등 다양한 응용에 적합하며, 높은 특이성과 재현성을 제공합니다. 항원 친화 크로마토그래피로 정제된 액상 형태 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | View 2 publications |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | GST fusion protein encoding the first 71 amino acids of rat KCNQ3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2131708 |
Product Specific Information
PA1-930 detects KCNQ3 from mouse, human, and rat samples.
This antibody is specific for KCNQ3 and does not detect KCNQ1, KCNQ2, KCNQ4, or KCNQ5.
PA1-930 has been successfully used in:
- Immunofluorescence
- Immunohistochemistry
- Immunocytochemistry
Immunohistochemical staining using PA1-930 yielded a strong signal mainly in interneurons and astrocytes in the dentate region of rat hippocampal samples.
The immunogen is a GST fusion protein encoding the first 71 amino acids of rat KCNQ3.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family.
There are five known KCNQs (KCNQ1–5) found in the central nervous system, with KCNQ2 and KCNQ3 playing key roles in M-current activation.
KCNQ2 and KCNQ3 form heteromultimers that significantly increase the M-current, which controls neuronal excitability and synaptic responsiveness.
Genetic mutations in these proteins have been linked to disorders such as:
- Benign familial neonatal convulsions (BFNC)
- Deafness
- Neuropathic pain
- Epilepsy
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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