Thermo Fisher Scientific KCNQ2 Polyclonal Antibody
KCNQ2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 0.5 µg/mL | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | GST fusion protein encoding the first 70 amino acids of human KCNQ2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2131689 |
Product Specific Information
PA1-929 detects KCNQ2 from mouse, human, and rat samples. This antibody is specific for KCNQ2 and does not detect KCNQ1, KCNQ3, KCNQ4, or KCNQ5.
It has been successfully used in Western blot, immunofluorescence, immunohistochemistry, and immunocytochemistry applications.
Immunohistochemical staining of rat hippocampal tissue using PA1-929 shows strong signals in the granule cell layer and mossy fibers of the dentate gyrus.
The immunogen is a GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family.
There are five known KCNQs (KCNQ1–5) found in the central nervous system, with KCNQ2 and KCNQ3 being crucial for M-current activation.
KCNQ2 and KCNQ3 form heteromultimers that increase M-current amplitude, influencing neuron excitability and synaptic responsiveness.
Mutations in these proteins are linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain, and epilepsy.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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