Thermo Fisher Scientific AIF Polyclonal Antibody
Apoptosis Inducing Factor(AIF)을 인식하는 Rabbit Polyclonal Antibody로, Western Blot에 적합합니다. 합성 펩타이드(109–122 residues of human AIF)를 면역원으로 사용하며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능하며, K562 cell lysate를 양성 대조로 권장합니다.
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 109–122 of human AIF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1077489 |
Product Specific Information
A suggested positive control for this product is K562 cell lysate.
Target Information
Apoptosis Inducing Factor (AIF) causes chromatin condensation and DNA fragmentation. AIF localizes in mitochondria and translocates to the nucleus upon induction of apoptosis, facilitating release of apoptogenic proteins such as cytochrome c and caspase-9.
AIF is highly conserved between human and mouse and widely expressed. Mutations in the AIF gene cause combined oxidative phosphorylation deficiency 6, resulting in severe mitochondrial encephalomyopathy.
Alternative splicing produces multiple transcript variants, and a related pseudogene is identified on chromosome 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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