Thermo Fisher Scientific ADAM10 Polyclonal Antibody
ADAM10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 Immunocytochemistry에 사용 가능하며, Jurkat cell lysate를 양성 대조군으로 추천합니다. -20°C 보관, 연구용 전용 제품입니다.
- 카탈로그번호
- PA112500
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ADAM10 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.25–1 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 732–748 of ADAM10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1069992 |
Product Specific Information
This antibody is expected to cross-react with bovine samples due to sequence homology.
A suggested positive control for this product is Jurkat whole cell lysate.
Target Information
Proinflammatory cytokine tumor necrosis factor-α (TNF-α) contributes to a variety of inflammatory responses and programmed cell death.
Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including T-cell lymphoma.
TNF-α, Notch, and its ligand delta are membrane-bound molecules cleaved by proteases to release mature proteins or functional receptors.
ADAM10, a metalloprotease-disintegrin in the mammalian ADAM family (a disintegrin and metalloprotease), was identified to cleave TNF-α, Notch, and its ligand delta.
The genes encoding human, mouse, and bovine ADAM10 were cloned and designated ADAM10, kuzbanian (KUZ), and MADM, respectively.
ADAM10 mRNA is expressed in various human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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