Thermo Fisher Scientific SOD2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing MnSOD (SOD2) in multiple species. Validated for WB, IHC(P), and ICC/IF applications. Suitable for detecting mitochondrial antioxidant enzyme SOD2. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
Product Specifications
| Specification | Detail |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant human MnSOD (manganous superoxide dismutase) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
| RRID | AB_2539890 |
Product Specific Information
PA1-125 recognizes MnSOD in bovine, human, mouse, and rat samples and has been used in WB and IHC(P) applications.
This antibody was originally validated as part of a Thermo Scientific Cellomics High Content Screening Kit.
The antibody sold separately may have slightly different performance and may need further optimization for best results.
Target Information
Superoxide dismutase (SOD) is an antioxidant enzyme involved in defense against reactive oxygen species (ROS).
SOD catalyzes the dismutation of superoxide radical anion (O₂⁻) to hydrogen peroxide (H₂O₂), which is further converted to water and oxygen by glutathione peroxidase and catalase.
Several classes of SOD have been identified:
- SOD1 (Cu, Zn-SOD): Intracellular, homodimeric enzyme (~32 kDa)
- SOD2 (Mn-SOD): Mitochondrial, tetrameric enzyme (~80 kDa)
- SOD3 (EC-SOD): Extracellular, heparin-binding multimer
- SOD4 (CCS): Copper chaperone for SOD1, delivering Cu cofactor
SOD2 is located in the mitochondrial matrix, near the respiratory chain, a primary source of superoxide generation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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