Thermo Fisher Scientific Phospho-MYH9 (Ser1803) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

This antibody was cross-adsorbed to unphosphorylated Myosin IIA Heavy Chain (Ser-1803) peptide before affinity purification using phospho-Myosin IIA Heavy Chain (Ser-1803) peptide (without carrier).
The antibody detects a 200 kDa* protein corresponding to Myosin IIA Heavy Chain on SDS-PAGE immunoblots of human A431 cells treated with Calyculin A.
This reactivity is removed after treatment with lambda phosphatase.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.

• The MYH9 gene spans over 106 kilobases and includes 41 exons encoding a 1,960-amino-acid protein.
• NMHC IIA forms a hexameric complex with two heavy chains, two regulatory light chains, and two essential light chains.
• It interacts with actin filaments, contributing to cell migration, adhesion, division, and shape maintenance.
• Mutations in MYH9 cause autosomal dominant MYH9-related diseases (MYH9-RD) such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome.
• These disorders are associated with macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.
• MYH9 is essential for hematopoiesis, maintaining hematopoietic stem and progenitor cells (HSPCs). Loss of function can result in severe blood cell deficiencies and bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.