Thermo Fisher Scientific CCR4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gorilla, Gibbon, Monkey, Marmoset (100%);
  Ferret, Elephant, Panda (94%);
  Dog, Bovine, Bat, Hamster (89%);
  Mouse, Rat (83%).

• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

CCR4 is a chemokine receptor preferentially expressed on type 2 helper T (Th2-type) cells.
Unlike other chemokine receptors, CCR4 and CCR8 expression on Th2 cells increases transiently following TCR and CD28 engagement.
Activated Th1 cells also up-regulate CCR4 expression and responsiveness to thymus- and activation-regulated chemokine.

Chemokines are small (approximately 8–14 kD), mostly basic molecules that regulate leukocyte trafficking via 7-transmembrane, G protein-coupled receptors.
They play key roles in immune system development, homeostasis, and function, and also affect CNS cells and endothelial cells in angiogenesis or angiostasis.
Chemokines are divided into two major subfamilies, CXC and CC, based on the arrangement of conserved cysteine residues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.