Thermo Fisher Scientific CCR4 Polyclonal Antibody
CCR4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ELISA에 사용 가능. 인간 CCR4 C-말단 세포질 도메인 합성 펩타이드로 면역화됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 5–10 µg/mL
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human CCR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550160 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Marmoset (100%); Monkey, Elephant (94%); Hamster (88%); Dog, Panda, Horse (81%) - For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
CCR4 is a chemokine receptor preferentially expressed on type 2 helper T (Th2-type) cells.
Unlike other chemokine receptors, CCR4 and CCR8 expression on Th2 cells transiently increases after TCR and CD28 engagement.
Activated Th1 cells also up-regulate CCR4 expression and responsiveness to thymus- and activation-regulated chemokine.
Chemokines are small (8–14 kD), mostly basic molecules that regulate leukocyte trafficking via 7-transmembrane, G protein-coupled receptors.
They play essential roles in immune system development, homeostasis, and function, and affect CNS and endothelial cells involved in angiogenesis or angiostasis.
Chemokines are divided into two major subfamilies:
- CXC chemokines: Two conserved cysteines separated by one amino acid
- CC chemokines: Two adjacent conserved cysteines
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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