Thermo Fisher Scientific CCR8 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gorilla, Monkey (100%); Gibbon, Marmoset (95%); Bovine, Horse (84%)
• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
• After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into inflammatory sites. This receptor protein is preferentially expressed in the thymus.
Ligands identified for this receptor include I-309, thymus activation-regulated cytokine (TARC), and macrophage inflammatory protein-1 beta (MIP1 beta).
Studies suggest CCR8 plays a role in regulation of monocyte chemotaxis and thymic cell apoptosis, contributing to proper positioning of activated T cells within antigenic challenge sites and specialized lymphoid tissues.
CCR8 expression has been reported in spleen, thymus, natural-killer cells, monocytes, T cells, and at lower levels in peripheral blood leukocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.