Thermo Fisher Scientific Phospho-NMDAR2B (Tyr1336) Polyclonal Antibody
Phospho-NMDAR2B (Tyr1336) 폴리클로날 항체로, 인산화된 NMDAR2B 단백질의 Tyr1336 부위를 특이적으로 검출합니다. Western blot, IHC, ICC/IF에 사용 가능하며 인간, 생쥐, 랫드 반응성을 갖습니다. 신경 발달 및 시냅스 가소성 연구에 적합합니다.
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- PA5104985
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Thermo Fisher Scientific Phospho-NMDAR2B (Tyr1336) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human GRIN2B (Accession Q13224), corresponding to amino acid residues around phosphorylated Tyr1336 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816458 |
Product Specific Information
This antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyrosine 1336.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency linked to memory and learning. NMDAR2B plays a role in neuronal development and is implicated in disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression is observed in aged or memory-impaired animals. Phosphorylation at Tyr1472 may increase synaptic NMDAR expression, contributing to synaptic plasticity. NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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