Thermo Fisher Scientific Phospho-AMPK alpha-1 (Ser486) Polyclonal Antibody
AMPK alpha-1 단백질의 Ser486 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능하며 인간, 마우스, 랫트 반응성. 고순도, 1 mg/mL 농도, PBS/glycerol buffer로 안정적 보관.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKAA1 (Accession Q13131), corresponding to amino acid residues around phosphorylated Ser486. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816455 |
Product Specific Information
Antibody detects endogenous levels of AMPK alpha 1 only when phosphorylated at Ser486 (Isoform 1).
Target Information
Protein kinases are enzymes that transfer a phosphate group from a donor molecule, typically ATP, to an acceptor amino acid residue in a substrate protein. Through this mechanism, they regulate signal transduction in eukaryotic cells, influencing metabolism, transcription, cell cycle progression, cytoskeletal dynamics, cell movement, apoptosis, and differentiation. The protein kinase family includes over 500 gene products and is classified into eight major groups based on catalytic domain sequence similarities.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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