Thermo Fisher Scientific QKI Monoclonal Antibody (GT228)
QKI 단백질 검출용 Mouse monoclonal antibody (Clone GT228). Western blot 및 IHC(Paraffin)에서 높은 특이성과 재현성 제공. Human, Mouse, Rat 등 다양한 종에 반응. 단백질 A로 정제된 액상 형태, 장기 보관 시 -20°C 권장.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT228 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human QKI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787196 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Xenopus laevis (93%), Dog (100%), Cat (100%), Pig (100%), Chicken (98%), Bovine (100%).
- Positive Control: 293T mock and shQKI.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus.
The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles, and at low levels in the pancreas.
This gene includes a very large exon spanning more than 12.8 kb.
Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy.
Sacsin has been found to protect against mutant ataxin-1.
A pseudogene associated with this gene is located on chromosome 11.
Alternative splicing of this gene results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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