Thermo Fisher Scientific TDP-43 Monoclonal Antibody (GT6310)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as a concentrated solution.
• Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (83%), Xenopus laevis (91%), Chicken (95%), Bovine (96%).
• Positive Control: 293T.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR. Later studies revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3′ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.