Thermo Fisher Scientific TDP-43 Monoclonal Antibody (GT6310)
TDP-43 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 면역조직화학(IHC) 분석에 적합합니다. 다양한 종에 반응하며, 단백질 발현 연구 및 신경퇴행성 질환 연구에 유용합니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT6310 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human TDP43 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787198 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (83%), Xenopus laevis (91%), Chicken (95%), Bovine (96%).
- Positive Control: 293T.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts as a transcriptional repressor to the HIV-1 LTR. Later studies revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR), likely through association with UG repeats at the 3′ splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43, known as pathologic TDP43, is the major disease protein in ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, an RNA-binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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