Thermo Fisher Scientific PYK2 Monoclonal Antibody (GT1132)
PYK2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot과 IHC(Paraffin)에 적합합니다. 인간 및 마우스에 반응하며, 단백질 G 정제 및 PBS 용액 형태로 제공됩니다. 세포 이동, 신호전달 연구에 활용 가능.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT1132 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human PYK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787194 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (92%), Rat (93%), Bovine (94%).
- Positive Control: A431.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, migration, adhesion, spreading, and bone remodeling. It plays a role in humoral immune response regulation, maintaining marginal B-cell levels in the spleen, and normal B-cell migration. It functions in signaling downstream of integrin, collagen, immune, G-protein coupled, cytokine, chemokine, and growth factor receptors, mediating responses to cellular stress.
Aberrant FAK2 expression may contribute to cancer cell proliferation, migration, and invasion. Elevated expression has been observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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