Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Arginase 1. Validated for WB and IHC (Paraffin). High specificity with recombinant protein immunogen. Supplied as liquid, 0.1 mg/mL, in PBS with glycerol. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,500–1:5,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARG1. Recombinant protein control fragment (Product # RP-99365) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790017 |
Product Specific Information
Immunogen sequence:
GLRDVDPGEH YILKTLGIKY FSMTEVDRLG IGKVMEETLS YLLGRKKRPI HLSFDVDGLD PSFTPATGTP VVGGLTYREG LYITEEIYKT GLLSGLDIME VNPSLGKTPE EVTRTVNTAV AITL
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The generated polyamines are crucial for cell proliferation and detoxification. By degrading arginine, Arginase 1 limits nitric oxide production by depriving NO synthase of its substrate.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in tumor-infiltrating myeloid cells and is commonly detected in hepatocellular carcinomas.
Defects in the ARG1 gene cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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