Thermo Fisher Scientific Arginase 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
GLRDVDPGEH YILKTLGIKY FSMTEVDRLG IGKVMEETLS YLLGRKKRPI HLSFDVDGLD PSFTPATGTP VVGGLTYREG LYITEEIYKT GLLSGLDIME VNPSLGKTPE EVTRTVNTAV AITL

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle. The generated polyamines are crucial for cell proliferation and detoxification. By degrading arginine, Arginase 1 limits nitric oxide production by depriving NO synthase of its substrate.
In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not in CCR3+ granulocytes. In mice, Arginase 1 is a hallmark of alternatively activated macrophages (M2a). It may also be expressed in tumor-infiltrating myeloid cells and is commonly detected in hepatocellular carcinomas.
Defects in the ARG1 gene cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.