Thermo Fisher Scientific Phospho-MYH9 (Ser1943) Monoclonal Antibody (GT144)
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Phospho-MYH9 (Ser1943) 단일클론 항체로 인간 MYH9 단백질의 인산화 형태를 검출. Western blot, IHC, ICC/IF에 적합. 단백질 G 정제, PBS buffer, 무보존제. 세포 이동 및 골수형성 연구에 활용 가능.
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Thermo Fisher Scientific Phospho-MYH9 (Ser1943) Monoclonal Antibody (GT144)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT144 |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MYH9 (phospho Ser1943). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735314 |
Product Specific Information
- Positive Control: 293T, A431, HeLa, HepG2
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton.
It plays essential roles in cellular processes such as migration, adhesion, division, and maintenance of cell shape.
- Gene structure: spans over 106 kilobases, includes 41 exons, encoding a protein of 1,960 amino acids.
- Protein complex: hexameric structure with two heavy chains, two regulatory light chains, and two essential light chains.
- Clinical relevance: mutations cause MYH9-related diseases (MYH9-RD) such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential hearing loss, renal failure, or cataracts.
- Role in hematopoiesis: essential for hematopoietic stem and progenitor cell survival; loss of function leads to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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