Thermo Fisher Scientific MYH9 Monoclonal Antibody (GT218)
MYH9 단백질을 표적으로 하는 Thermo Fisher Scientific의 GT218 단클론 항체로, Western blot, IHC, Flow cytometry 등에 적합. 인간 및 마우스 반응성, Protein A로 정제된 액상 형태. 세포골격 연구 및 MYH9 관련 질환 연구용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Flow Cytometry (Flow) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Dog |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT218 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human MYH9. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735282 |
Product Specific Information
- Positive Control: A431
- Predicted Reactivity: Rat (97%), Xenopus laevis (89%), Dog (99%), Chicken (94%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton involved in cell migration, adhesion, division, and shape maintenance.
MYH9 spans over 106 kilobases and includes 41 exons, encoding a 1,960 amino acid protein that forms a hexameric complex with light chains.
Mutations in MYH9 cause autosomal dominant disorders known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential hearing loss, renal failure, or cataracts.
MYH9 also plays a vital role in hematopoiesis, essential for hematopoietic stem and progenitor cell maintenance; its loss leads to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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