Thermo Fisher Scientific KCNQ4 Monoclonal Antibody (N43/6), APC
KCNQ4 단백질을 표적하는 APC 결합 마우스 단일클론 항체로, WB, IHC, ICC, IP 등 다양한 응용에 사용 가능. 사람, 생쥐, 랫트 반응성. 단백질 G 정제, 액상 형태, 4°C 보관. 651/660 nm 형광 특성으로 세포 분석 및 신경 흥분성 연구에 적합.
- 판매단위
- pk
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Thermo Fisher Scientific KCNQ4 Monoclonal Antibody (N43/6), APC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N43/6 |
| Immunogen | Fusion protein amino acids 2–77 of human KCNQ4 |
| Conjugate | APC |
| Excitation/Emission Max | 651/660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931865 |
Additional Formats
- Unconjugated: MA5-27653
- FITC: MA5-45412
- PE: MA5-45414
- PerCP: MA5-45413
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45411 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 77 kDa.
Target Information
The protein encoded by this gene forms a potassium channel that plays a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, an anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel with KCNQ3. Defects in this gene cause nonsyndromic sensorineural deafness type 2, an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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