Thermo Fisher Scientific GATM Monoclonal Antibody (OTI1E3), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
When using this carrier-free antibody for conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM, or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family.
Encoded by a gene located on human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and typically forms a homodimer.
AGAT localizes to mitochondrial inner and peripheral membranes as well as the cytoplasm. It is expressed in various tissues including brain, heart, liver, lung, salivary gland, skeletal muscle, and kidney.
AGAT is involved in the biosynthesis of guanidinoacetate, a precursor of creatine, which is essential for energy metabolism in muscle tissues.
Defects in AGAT are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, and severe depletion of creatine/phosphocreatine in the brain.
AGAT may play roles in embryonic and central nervous system development and in cardiac response during heart failure by elevating local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.