Thermo Fisher Scientific Nurr1 Polyclonal Antibody

Applications

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.

Nurr1 is a transcription factor belonging to the Nur77 family of orphan receptors. This family plays key roles in T lymphocyte development and effector functions. Nurr1 promotes signaling via its heterodimerization partner, the retinoid X receptor (RXR).

Nurr1 protein is expressed in the embryonic ventral midbrain and is critical for the development of dopamine neurons. It is also implicated in the maintenance of adult dopaminergic neurons.

GenScript Nurr1 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 310–360 of human Nurr1 protein (Swiss Prot: P43354).

Target Information

The Nuclear receptor related 1 protein (Nurr1, also known as NR4A2) is encoded by the NR4A2 gene in humans. Nurr1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.

Mutations in this gene have been associated with disorders involving dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis.

Four transcript variants encoding distinct isoforms have been identified for this gene, and additional alternate splice variants may exist but are not fully characterized.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.