Thermo Fisher Scientific GSTM1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. Eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the mu class, which functions in detoxification of electrophilic compounds—including carcinogens, therapeutic drugs, environmental toxins, and oxidative stress products—by conjugation with glutathione.
The mu class genes are clustered on chromosome 1p13.3 and are highly polymorphic, influencing susceptibility to carcinogens and drug responses. Null mutations in this gene are associated with increased cancer risk due to reduced detoxification capacity. Multiple isoforms are encoded by transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.