Thermo Fisher Scientific GSTA1/A2/A3/A4/A5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione.
The genes encoding these enzymes are highly polymorphic, affecting susceptibility to carcinogens and toxins as well as drug toxicity and efficacy.
Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the alpha class, located in a cluster on chromosome 6, abundantly expressed in liver and kidney.
In addition to metabolizing bilirubin and certain anti-cancer drugs, the alpha class enzymes exhibit glutathione peroxidase activity, protecting cells from reactive oxygen species and peroxidation products.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.