Thermo Fisher Scientific CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), eBioscience
인간 CD157(BST-1)을 인식하는 eBioSY11B5 단클론 항체로, Flow Cytometry, WB, IHC(F), IP 등에 사용 가능. 비결합형 액상 형태이며 0.5 mg/mL 농도. 높은 순도(>90%)와 낮은 응집도(<10%)를 가지며 연구용으로 적합.
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Thermo Fisher Scientific CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Flow Cytometry (Flow) | 0.5 µg/test |
| Immunoprecipitation (IP) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioSY11B5 (SY11B5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864999 |
| Purity | >90%, determined by SDS-PAGE |
| Aggregation | <10%, determined by HPLC |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Conjugated Formats
- Alexa Fluor 488
- APC
- NovaFluor Blue 660-120S
- NovaFluor Red 710
- NovaFluor Yellow 590
- NovaFluor Yellow 610
- PE
- PE-Cyanine7
- Super Bright 436
- Super Bright 600
- Custom conjugation available upon request
Product Specific Information
The eBioSY11B5 monoclonal antibody recognizes human CD157 (Mo5, BST-1). CD157 is a 42–45 kDa, GPI-anchored protein structurally and functionally similar to CD38. Initially identified on monocytes and macrophages, it was later found to be identical to BST-1, expressed on bone marrow stromal cells and capable of stimulating pre-B cell proliferation.
CD157 functions both as an ectoenzyme and receptor, involved in NAD⁺ metabolism and intracellular Ca²⁺ regulation. Upon ligand binding, CD157 may trigger signal transduction cascades leading to phosphorylation of cytoplasmic proteins such as focal adhesion kinase (FAK). The detailed mechanism remains under investigation.
Applications Reported: Flow cytometry, immunoprecipitation, immunoblotting (non-reduced), and immunohistology of frozen sections.
Applications Tested: Flow cytometric analysis of normal human peripheral blood cells at ≤0.5 µg/test (100 µL final volume, 10⁵–10⁸ cells/test). Titrate as needed for optimal assay performance.
Target Information
Bone marrow stromal cell antigen 1 (BST1) is a GPI-anchored molecule facilitating pre-B cell growth. Also known as ADP-ribosyl cyclase 2 and DAMP-1, BST1 expression is enhanced in bone marrow stromal cells from rheumatoid arthritis patients. BST1 overexpression may contribute to polyclonal B cell abnormalities in rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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