Thermo Fisher Scientific ATG4C Polyclonal Antibody
ATG4C 단백질을 인식하는 Thermo Fisher Scientific의 sheep polyclonal 항체입니다. Western blot 및 IHC에 사용 가능하며 인간, 마우스, 랫트 반응성 보유. 자가포식 관련 연구용으로 적합하며, 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
- 카탈로그번호
- OSA00004W-150UL
- 판매단위
- pk
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Thermo Fisher Scientific ATG4C Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:5,000 | – |
| Immunohistochemistry (IHC) | 1:200–1:5,000 | – |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to human, rat, and mouse cysteine protease ATG4C (autophagin-3, APG4C, AUTL1, AUTL3) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ATG4C.
Target Information
ATG4C is involved in autophagy, the process by which endogenous proteins and damaged organelles are degraded intracellularly. Autophagy is essential for cell homeostasis and remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced autophagy levels have been observed in some malignant tumors, suggesting a role in controlling unregulated cell growth linked to cancer.
This gene encodes a member of the autophagin protein family and the C-54 cysteine protease family. Alternate splice variants encoding the same protein have been characterized.
ATG4C cleaves the C-terminal part of MAP1LC3, GABARAPL2, or GABARAP, liberating form I, which is subsequently converted to form II (PE-conjugated form) capable of binding autophagosomes.
Highly expressed in skeletal muscle, heart, liver, and testis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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