Thermo Fisher Scientific ATG3 Polyclonal Antibody
ATG3 단백질을 인식하는 Thermo Fisher Scientific의 양친양성 폴리클로날 항체. Western blot 및 IHC에 사용 가능하며, 인간 ATG3 합성 펩타이드로 면역화됨. 연구용으로만 사용되며 자가포식 관련 단백질 분석에 적합.
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- OSA00005W
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:2,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human autophagy-related protein 3 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2064387 |
Product Specific Information
Reconstitute with 150 µL of distilled water.
Centrifuge to remove any insoluble material.
Target Information
ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomal-lysosomal pathway, is important for normal growth control and may be defective in tumor cells.
Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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