Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Arg3.1/ARC 단백질을 인식하는 Sheep 유래 Polyclonal Antibody로, WB 및 IHC에 사용 가능. 인간, 생쥐, 랫트 반응성. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C에서 안정적. 신경 시냅스 가소성 연구에 적합.
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- OSA00001W-100UL
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Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides from human Arg3.1 (ARC) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity of this antibody: Arg3.1/ARC.
Target Information
Arg3.1 (ARC) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs, mediating intercellular RNA transfer in the nervous system. ARC protein is released from neurons via extracellular vesicles, transferring ARC mRNA into target cells for activity-dependent translation.
It plays a key role in long-term potentiation (LTP), long-term depression (LTD), and memory formation by regulating AMPA receptor endocytosis and synaptic scaling. Additionally, ARC mediates synapse elimination in developing cerebellum and contributes to neuronal homeostasis.
ARC is also involved in postsynaptic trafficking of amyloid-beta A4 (APP) and expressed in skin-migratory dendritic cells, regulating T-cell activation through dendritic cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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