Thermo Fisher Scientific SCF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL
• Publications: - References

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10–20 µg/mL
• Publications: - References

Product Specifications

Product Specific Information

• In Western blots, approximately 60% cross-reactivity with recombinant mouse SCF is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

Stem Cell Factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase.
SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting therapeutic potential in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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