Thermo Fisher Scientific FGFR4 Polyclonal Antibody
Thermo Fisher Scientific FGFR4 Polyclonal Antibody는 Mouse FGFR4 단백질을 인식하는 Goat 유래 IgG 항체로, Western blot 및 IHC(Frozen)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 5% trehalose buffer에 보존됩니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.25 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse FGF R4 (Leu19–Asp366) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608140 |
Product Specific Information
- In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) FGF R4 is observed.
- 5% cross-reactivity with rhFGF R1 alpha (IIIb), rhFGF R1 alpha (IIIc), and rhFGF R1 beta (IIIb) is observed.
- Less than 1% cross-reactivity with recombinant mouse (rm) FGF R2 alpha (IIIb), rmFGF R2 beta (IIIb), rmFGF R2 beta (IIIc), rmFGF R3 alpha (IIIb), rmFGF R3 alpha (IIIc), rmFGF R5, and rmFGF R5 beta is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg of antibody (LAL method).
Target Information
FGFR4 (Fibroblast Growth Factor Receptor 4) is a receptor tyrosine kinase involved in diverse cellular processes such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, and tissue repair.
It regulates CYP7A1 expression in response to FGF19, influencing bile acid synthesis. FGFR4 also plays roles in postnatal lung development and skeletal muscle lineage formation.
The FGFR family is associated with diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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