
Thermo Fisher Scientific IL17RD Polyclonal Antibody
IL17RD 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot, IHC, Flow Cytometry에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-17RD/SEF (Ala27–Arg299) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606536 |
Product Specific Information
- In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse (rm) IL-17RD is observed.
- Less than 10% cross-reactivity with recombinant human (rh) IL-17RC, rmIL-17B R, and rhIL-17R is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
IL17RD acts as a feedback inhibitor of fibroblast growth factor (FGF)-mediated Ras-MAPK signaling and ERK activation.
It may inhibit FGF-induced FGFR1 tyrosine phosphorylation and regulate nuclear ERK signaling by preventing nuclear translocation of activated ERK without affecting cytoplasmic phosphorylation.
It also mediates JNK activation and may play a role in apoptosis and early fate specification of GnRH-secreting neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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