Thermo Fisher Scientific Lamin A (Cleaved Asp230) Monoclonal Antibody (C.69.9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

C.69.9

Immunogen

Synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Lamin A (Cleaved Asp230),uniProtId:P02545-1,ncbiNodeId:9606,antigenRange:1,antigenLength:664,antigenImageFileName:MA5-15211_Lamin_A_Cleaved_Asp230_P02545-1_House_mouse.svg,antigenImageFileNamePDP:MA5-15211_Lamin_A_Cleaved_Asp230_P02545-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10985208

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with full length lamin A or C.

Target Information

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.