Thermo Fisher Scientific Lamin A (Cleaved Asp230) Monoclonal Antibody (C.69.9)
Lamin A 단백질의 Asp230 절단 부위를 인식하는 Thermo Fisher monoclonal antibody. 인간, 생쥐, 랫트 시료에 반응하며 WB 및 ICC/IF에 적합. 고순도 affinity chromatography로 정제, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C.69.9 |
| Immunogen | Synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 µg/mL |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_10985208 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with full length lamin A or C.
Target Information
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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