Thermo Fisher Scientific Phospho-EGFR (Tyr1068) Monoclonal Antibody (S.684.2)
EGFR 단백질의 Tyr1068 인산화 부위를 특이적으로 인식하는 단클론 항체. Western blot, ICC/IF, IP 등 다양한 응용에 적합. 인간, 영장류, 랫드 반응성. 고순도 친화 크로마토그래피 정제. -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.684.2 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr1068 of human EGF receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1865 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985111 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression of EGFR has been associated with multiple cancer types, making it a key target for both biological and small-molecule therapeutics.
The EGFR gene is located on chromosome 7 in humans and belongs to the HER/ERbB family, which includes ERbB2, ERbB3, and ERbB4. EGFR is a transmembrane receptor; binding of ligands such as EGF or TGF-α to its extracellular domain induces receptor dimerization and autophosphorylation of cytoplasmic tyrosine residues.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach, and in squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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