Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1/1447)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–2 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/10^6 cells

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits may serve as plasma carrier molecules without enzymatic activity. Platelet factor XIII consists of two A subunits identical to those of plasma origin. Upon cleavage by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits and yields the active enzyme factor XIIIa, identical to platelet factor XIII. This enzyme acts as a transglutaminase, catalyzing γ-glutamyl-ε-lysine crosslinking between fibrin molecules to stabilize the fibrin clot. It also crosslinks α2-plasmin inhibitor or fibronectin to the α chains of fibrin. Factor XIII deficiency is classified into two categories:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit alone

These defects can cause lifelong bleeding tendency, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.