Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1, 1448)

Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1, 1448)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Coagulation factor XIII is the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic activity, while the B subunits serve as carrier molecules. Platelet factor XIII consists only of two A subunits identical to those in plasma. Upon activation by thrombin and calcium, the B subunits dissociate, forming active factor XIIIa, which catalyzes crosslinking between fibrin molecules, stabilizing the clot. Factor XIII also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin. Deficiency types include:

• Type I: Lack of both A and B subunits
• Type II: Lack of A subunit only

These deficiencies can lead to lifelong bleeding tendency, poor wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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