Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1/1447)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–2 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 1–2 µg/10^6 cells

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules without enzymatic activity. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin.

Upon thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits to yield the active enzyme factor XIIIa, identical to platelet factor XIII. This enzyme functions as a transglutaminase, catalyzing gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thereby stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin.

Factor XIII deficiency is categorized into:

• Type I deficiency: Lack of both A and B subunits
• Type II deficiency: Lack of A subunit only

These deficiencies can cause lifelong bleeding tendencies, defective wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.