Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1/1447)
인간 Factor XIIIa를 인식하는 단일클론 항체로, ICC/IF, Flow Cytometry, ELISA 등에 사용 가능. 고순도 Protein A/G 정제, 200 µg/mL 농도. 연구용으로 혈액 응고 인자 XIIIa의 기능 분석 및 관련 단백질 연구에 적합.
- 카탈로그번호
- 2162-MSM1-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1/1447)
Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F13A1/1447 |
| Immunogen | Recombinant fragment of human Factor XIIIa protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules without enzymatic activity. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin.
Upon thrombin cleavage and in the presence of calcium ions, plasma factor XIII dissociates its B subunits to yield the active enzyme factor XIIIa, identical to platelet factor XIII. This enzyme functions as a transglutaminase, catalyzing gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thereby stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin.
Factor XIII deficiency is categorized into:
- Type I deficiency: Lack of both A and B subunits
- Type II deficiency: Lack of A subunit only
These deficiencies can cause lifelong bleeding tendencies, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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