Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1, 1448)
Factor XIIIa(F13A1,1448) 단클론 항체로 Western blot, IHC, ICC/IF, Flow cytometry 등 다양한 응용에 사용 가능. 인간 시료 반응성, Mouse IgG2b 아이소타입. 단백질 A/G 정제, PBS 기반 완충액에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F13A1, 1448 |
| Immunogen | Recombinant fragment of human Factor XIIIa protein (aa46–181) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA-fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cooling at room temperature for 20 minutes.
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic activity, while the B subunits act as carrier molecules. Platelet factor XIII consists only of two A subunits identical to those in plasma.
Upon activation by thrombin and calcium ions, plasma factor XIII dissociates its B subunits to yield the active enzyme, factor XIIIa. This enzyme functions as a transglutaminase, catalyzing crosslinking between fibrin molecules to stabilize the clot. It also crosslinks α2-plasmin inhibitor or fibronectin to fibrin α chains. Factor XIII deficiency can be type I (lack of A and B subunits) or type II (lack of A subunit only), leading to bleeding tendency, poor wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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