Thermo Fisher Scientific Phospho-c-Abl (Tyr226) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Antibody detects endogenous levels of c-Abl only when phosphorylated at Tyr226, which site historically referenced as Tyr245.

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of this domain converts c-Abl into an oncogene.
CDC2-mediated phosphorylation regulates the DNA-binding activity of ABL1, suggesting a role in the cell cycle.
In chronic myelogenous leukemia and certain acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation forming the Philadelphia chromosome, resulting in fusion with the Bcr gene.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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