Thermo Fisher Scientific Aminoacylase Monoclonal Antibody (15G2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive controls:
Rat kidney tissue lysate, human liver tissue lysate, rat liver tissue, human liver tissue, human kidney tissue, mouse small intestine tissue, SHSY5Y.

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids. The gene is located on chromosome 3p21.1, a region often showing loss of heterozygosity in small-cell lung cancer (SCLC), where its expression is reduced or undetectable. The human aminoacylase-1 sequence is highly homologous to the porcine counterpart and represents the first member of a new family of zinc-binding enzymes. Mutations cause aminoacylase-1 deficiency, a metabolic disorder with CNS defects and increased urinary N-acetylated amino acids. Alternative splicing generates multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.