Thermo Fisher Scientific MECP2 Polyclonal Antibody
Rabbit polyclonal antibody for MECP2 detection in human, mouse, and rat. Validated for Western blot and IHC. Recognizes a conserved peptide (aa 469–486). Supplied as a liquid, 1 mg/mL, purified by antigen affinity chromatography. For research use only.
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- PA1888
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | View 2 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: C P(469) N R E E P V D S R T P V T E R V S(486) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | −20 °C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2281966 |
Product Specific Information
PA1‑888 detects methyl CpG binding protein 2 (MeCP2) from human, mouse, and rat cells and tissues.
It has been successfully used in Western blot procedures, detecting an ~56 kDa MeCP2 protein from AtT20 cell extract.
The immunizing peptide corresponds to amino acid residues 469–486 of human MeCP2, a sequence completely conserved in rat and mouse.
The immunizing peptide (Cat. # PEP‑121) is available for use in neutralization and control experiments.
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that contain a methyl‑CpG binding domain.
It binds specifically to methylated DNA, a key modification in eukaryotic genomes crucial for mammalian development.
MECP2 represses transcription from methylated gene promoters and, unlike other MBD family members, is X‑linked and subject to X inactivation.
While dispensable in stem cells, MECP2 is essential for embryonic development.
Mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurological developmental disorder and a common cause of mental retardation in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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