Thermo Fisher Scientific MECP2 Polyclonal Antibody
MECP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot, IHC-P, ICC/IF, IP 등에 적합하며, 항원 친화 크로마토그래피로 정제된 액상 시약입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1500 | View 6 publications |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:2000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Fruit fly, Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: M(1) V A G M L G L R E E K S E D(15) C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2143845 |
Product Specific Information
PA1-887 detects methyl CpG binding protein 2 (MeCP2) from human, mouse, and rat tissues and cells.
It has been successfully used in Western blot, IHC-P, immunofluorescence, and immunoprecipitation procedures.
By Western blot, this antibody detects an ~56 kDa protein representing MeCP2 from AtT20 cell extract.
PA1-887 immunizing peptide corresponds to amino acid residues 1–15 from mouse MeCP2, which is completely conserved in human MeCP2.
The immunizing peptide (Cat. # PEP-120) is available for use in neutralization and control experiments.
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that contain a methyl-CpG binding domain.
MECP2 binds specifically to methylated DNA, playing a crucial role in mammalian development and transcriptional repression of methylated gene promoters.
Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation.
Mutations in the MECP2 gene are the primary cause of Rett syndrome, a progressive neurological developmental disorder and a common cause of mental retardation in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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