Thermo Fisher Scientific MBD1 Polyclonal Antibody
Rabbit polyclonal antibody against human MBD1 protein for Western blot applications. Recognizes ~83 kDa recombinant MBD1. Antigen affinity purified, supplied in PBS with BSA and sodium azide. For research use only.
- 카탈로그번호
- PA1889
- 판매단위
- pk
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Applications
- Western Blot (WB): 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: C R(593) S K D L K K P G A R K Q(605) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2139592 |
Product Specific Information
PA1-889 detects human methyl CpG binding domain protein 1 (MBD1) recombinant protein.
It has been successfully used in Western blot procedures, detecting an ~83 kDa protein representing recombinant human MBD1.
The immunizing peptide corresponds to amino acid residues 593–605 from human MBD1 protein.
The immunizing peptide (Cat. # PEP-130) is available for use in neutralization and control experiments.
Target Information
Methyl-CpG-binding domain protein 1 (MBD1) is a mammalian protein that specifically binds methylated regions of DNA. It acts as a transcriptional repressor by binding CpG islands in promoters where DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by 7-mG produced by DNA damage (e.g., MMS exposure).
MBD1 contributes to gene silencing by recruiting AFT7IP, which in turn recruits factors such as histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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