Thermo Fisher Scientific NF1 Monoclonal Antibody (McNFn27a)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-084 detects neurofibromin in human, rat, and mouse cells.
It has been successfully used in Western blot procedures, detecting a ~230–260 kDa protein.
The immunogen is a synthetic peptide corresponding to the N-terminal residues 27–41 of human neurofibromin.

Target Information

The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi apparatus, presumably recycling between the two compartments.
It is a mannose-specific lectin and a member of a novel family of plant lectin homologs in the secretory pathway of animal cells.
Mutations in this gene are associated with a coagulation defect. The gene was identified as responsible for combined factor V-factor VIII deficiency, a rare autosomal recessive disorder in which both coagulation factors V and VIII are diminished.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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